I2C
hardwareInter-Integrated Circuit, a two-wire serial communication protocol for connecting low-speed peripherals
Pronunciation
Correct
eye-squared-see
/aɪ skwɛrd siː/
The '2' is read as 'squared' (I²C is the proper typographic form). The NXP Semiconductors specification, which defines the protocol, uses 'I-squared-C'.
Source: www.nxp.com(official spec)
Accepted Variants
Accepted Variant
eye-two-see
/aɪ tuː siː/
Pronouncing the '2' as 'two' rather than 'squared' is also widely accepted and understood, particularly in informal usage.
Source: en.wikipedia.org(community consensus)